Orthogonal sulfation strategy for synthetic heparan sulfate ligands.
نویسندگان
چکیده
[reaction: see text] An orthogonal sulfation strategy involving six different protecting groups has been developed for generating sulfated carbohydrate libraries based on heparan. Chemoselective cleavage conditions (optimized for a heparan disaccharide) can be performed in the presence of sulfate esters as well as the remaining protecting groups.
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ورودعنوان ژورنال:
- Organic letters
دوره 7 22 شماره
صفحات -
تاریخ انتشار 2005